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How to evaluate the performance of computational methods to identify driver...

We have recently published transFIC, a computational method to assess the functional impact of somatic cancer mutations (see this post). To evaluate the performance of transFIC we needed a dataset of...

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Oncodrive-CIS: a method to reveal likely driver genes based on the impact of...

One of the current challenges of oncogenomics is to elucidate which of the aberrations observed in the cancer genome is involved in the disease and which of them are just bystanders occurring...

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New IntOGen Somatic Mutations Analysis version available

We are proud to announce the brand new version of the IntOGen Somatic Mutations Analysis (IntOGen SM) pipeline. We call it version 2.0.0 as it has been completely rewritten from scratch with a strong...

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How to identify functional genetic variants in cancer genomes?

The possibility to rapidly and inexpensively sequence tumor genomes is opening important new avenues for cancer research. One of the main objectives when sequencing tumor genomes is to identify the...

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OncodriveCLUST: a method to reveal cancer drivers based on mutation clustering

We have recently developed a novel method, named OncodriveCLUST, aimed to analyse the mutations observed in sets of tumor samples and identify genes involved in the disease. It is based on the feature...

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My slides on: Identification of cancer drivers across tumor types

Yesterday I gave a talk at the PRBB Computational Genomics Seminars Series. In that talk I summarized our work of this year in the lab. Basically, we have developed methods to identify cancer driver...

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OncodriveROLE predicts activating and loss of function cancer driver genes

We are pleased to announce that the Oncodrive methods family has a new member: OncodriveROLE, an approach to classify cancer drivers into loss of function and activating roles. OncodriveROLE joins and...

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New IntOGen web to explore driver genes across cancer types

Coinciding with the publication of our latest paper, on Monday (9 March 2015) (See blog post) we have crafted a new IntOGen interface which presents the results of the analysis of somatic mutations...

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Our latest release of intOGen now available online!

We are very excited to release a new version of IntOGen, our framework to identify cancer genes and pinpoint putative mechanism of tumorigenesis. The IntOGen website displays new browsable content...

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Our review describing IntoGen titled “A compendium of mutational cancer...

In this review, we focus on the history of cancer driver genes identification from the beginning of cancer research through the advent of cancer genomics and into the future. We present a systematic...

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